Are GLP-1 Medications Safe, and What About Side Effects?

Safety is a top priority at Alloy. Each and every product we provide is safe, effective, and backed by science. GLP-1 medications are no different: The National Institute of Health has concluded that they do not present any significant safety issues when prescribed and monitored by a healthcare provider. 

As a part of our Weight Care Program, Alloy is offering three GLP-1 medications:

• Semaglutide (Wegovy®)

• Tirzepatide (Zepbound®)

• Compounded liraglutide

Each of these medications belongs to a class known as GLP-1 receptor agonists, which have been shown to support safe and sustainable weight loss.

How Do GLP-1 Weight Loss Medications Work? 

All of these are weight-loss medications that mimic the effects of GLP-1 (glucagon-like peptide-1), which is a naturally occurring hormone in the body that regulates appetite, digestion, and blood sugar levels. 

By slowing gastric emptying and enhancing insulin sensitivity, GLP-1 receptor agonists have been clinically proven to promote steady, sustainable weight loss, all while supporting healthy blood sugar control. It’s a science-backed, hormone-based approach to weight care that works with your body, not against it.

Who Is a Good Candidate for GLP-1 Medications like Semaglutide, Tirzepatide, and Compounded Liraglutide? 

GLP-1 medications may be a good fit for individuals who are struggling with weight loss despite lifestyle changes like diet and exercise. At Alloy, our medical team carefully evaluates each patient’s health history, goals, and risk factors to determine if GLP-1 therapy is a safe and effective option. See if you qualify

Who Should Avoid GLP-1 Medications Like Semaglutide, Tirzepatide, and Compounded Liraglutide?

Be assured that before prescribing a GLP-1 medication, your doctor will conduct a thorough medical consultation to see if you are a candidate for treatment, including making sure you do not have the following risk factors: 

• Allergic reactions

• Are pregnant or breastfeeding

• Low blood sugar (hypoglycemia)

• Personal or family history of medullary thyroid cancer

• Personal or family history of Multiple Endocrine Neoplasia Syndrome Type 2

• History of pancreatitis

Your safety is our top priority, and our clinical team will work with you to find the most effective and appropriate care plan based on your unique health profile. See if you qualify

Potential Side Effects of GLP-1 Medications Like Semaglutide, Tirzepatide, and Compounded Liraglutide

“Some people on GLP-1 medications have reported mild side effects including nausea, vomiting, diarrhea, constipation, and heartburn,” says Dr. Michelle Montville, Alloy’s Clinical Director. “These are generally mild to moderate, and, for most of the patients who experience them, improve over time as your body acclimates to the medication.” 

Common side effects may include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Heartburn

• Fatigue

• Headache

• Dizziness

• Injection site reactions

• Reduced appetite or changes in taste

Tips for Managing Side Effects from Semaglutide, Tirzepatide, and Compounded Liraglutide

You can help manage any side effects by taking advantage of the resources and tips Alloy provides as part of your Weight Care program. For example, eating small meals and prioritizing fiber can help with GI symptoms. If you are fatigued or dizzy, make sure you’re getting enough protein and hydrating. Those who experience heartburn should avoid spicy foods and can try elevating their head at night. And eating protein-forward mitigates potential side effects, while helping preserve lean muscle mass as you begin to lose weight.

Frequently Asked Questions About GLP-1 Medications for Weight Loss

How long can you be on GLP-1 medications?

GLP-1 medications can be taken long-term if they continue to be effective and well-tolerated. Your doctor will regularly evaluate your progress and make adjustments based on your goals, health markers, and how your body responds over time.

What happens when you stop taking GLP-1 medications?

If you stop taking a GLP-1 medication, your appetite and metabolism may gradually return to pre-treatment levels, which can lead to weight regain. That’s why it's important to pair the medication with sustainable lifestyle habits and ongoing support from your medical team.

Are there any foods you should avoid while taking GLP-1 medications?

Yes—processed foods, sugary drinks, high-fat meals, and carbonated beverages can worsen nausea or other GI side effects. Eating smaller, protein-rich meals and staying hydrated can help you feel your best while on treatment.

Can you drink alcohol while taking a GLP-1?

It’s best to limit or avoid alcohol while on GLP-1 medications, especially if you’re prone to nausea or low blood sugar. Alcohol can interfere with blood sugar control and increase the risk of side effects, so talk to your doctor about what's safe for you.

Partner with Alloy for Ongoing GLP-1 Support from Expert Physicians

You’ll stay in close contact with your doctor, who will monitor how you respond to the medication. In some cases, your doctor may suggest adjusting your dose or offer one of  three anti-nausea medications to manage potential side effects. 

For detailed safety information, read our Product Safety Mission Statement here. 

Weight Care at Alloy

We’re here to help you feel amazing in your body, inside and out. Our holistic program includes a customized plan created with a menopause-trained doctor, monthly check-ins and 24/7 messaging, and weight-loss medications. See more

Ready to see if you qualify? Start now

Sources

Smits MM, Van Raalte DH. Safety of semaglutide. Front Endocrinol (Lausanne). 2021;12:645563. doi:10.3389/fendo.2021.645563.