Why GLP-1s and MHT Are a Beneficial Combination

Here’s something that every midlife woman should know: Menopausal hormone treatment (MHT) has been shown to result in better distribution of body fat. Women taking MHT and trying to lose weight enjoy significantly better results compared to women not on MHT, according to researchers at the Mayo Clinic. That means MHT may do more than relieve menopausal symptoms—it could also enhance your body composition when combined with other weight management tools.

The Role of Hormones in Weight Management: How Does MHT Work for Weight Loss?

“MHT does not cause weight loss but may assist with fat redistribution, especially when paired with lifestyle changes,” says Dr. Michelle Montville, Alloy’s Clinical Director. The benefits come from MHT’s ability to alleviate many common menopausal symptoms—like hot flashes, night sweats, and sleep disturbances—that make it harder to lose weight. 

Take hot flashes, for example, which of course impact our sleep…the less we sleep and the more fatigued we are, the less likely we are to be physically active the next day. That makes it harder to manage our weight, full stop. By addressing these underlying hormonal disruptions, MHT helps create the conditions your body needs to respond more effectively to movement, nutrition, and, when needed, additional treatments like GLP-1 medications.

The Power of Combining MHT with Semaglutide

And there’s more good news for women who have tried, unsuccessfully, to manage their body composition through lifestyle changes, and are considering weight loss medication with their doctor. MHT and the GLP-1 medication semaglutide work together to improve weight loss results, according to a new study in the journal Menopause. 

In fact, women who were on MHT and semaglutide lost 30% more weight after 12 months than a control group of women who were on semaglutide but not hormone therapy. For midlife women navigating shifting hormones and stubborn weight, this combination can be a game-changer.

Beyond the Scale: Additional Health Benefits of MHT and GLP-1

There are other health benefits from the potent pairing of MHT and GLP-1s, such as reversing negative health issues like high blood pressure, high cholesterol, and osteoporosis. There are also positive mental and emotional benefits to reaching a healthy body weight in midlife. 

Mental & Emotional Benefits of Healthy Weight Loss for Women

Healthy weight loss in midlife isn’t just about the number on the scale—it’s about how you feel in your own skin. You may experience the confidence of regaining your strength, the excitement of boosting your energy, and the joy of improving your overall well-being. These effects are truly life-changing. In short: This combination of treatments helps you feel better, both inside and out. 

Frequently Asked Questions

Who is a good candidate for combining MHT with GLP-1s for weight management?

Women in perimenopause, menopause, or postmenopause who are struggling with stubborn weight gain and hormonal symptoms like hot flashes or fatigue may benefit from this combined approach. A medical consultation can help determine if MHT and GLP-1s are safe and effective based on your individual health profile.

Are there any risks to taking MHT & GLP-1s together?

For most women, combining MHT and GLP-1s is considered safe and well-tolerated. However, as with any medical treatment, there are potential risks—such as hormonal sensitivity or gastrointestinal side effects—which is why ongoing monitoring with a healthcare provider at Alloy is essential.

Can you start both GLP-1 and MHT treatments at the same time?

Yes, many women begin both treatments simultaneously after a thorough consultation with the doctors at Alloy. In some cases, your provider may recommend starting one therapy first and adding the second shortly after, depending on your symptoms and goals.

Do I need to be in menopause to experience the benefits of MHT & GLP-1s?

Not necessarily—many women in perimenopause experience symptoms that MHT can help relieve, especially when paired with GLP-1 medications for weight management. Whether you’re approaching, in, or past menopause, your doctor can tailor a plan to your specific stage of life.

Our Unique Approach: Hormone Therapy & GLP-1 Medications at Alloy

Our holistic Weight Care program is unique because we offer both MHT and GLP-1 weight loss medications together, a super-powered combination. And doctors are here to discuss possible solutions if you have concerns, questions, or think you may benefit from hormone therapy and/or weight loss medication. We want you to feel your best.

Weight Care at Alloy

We’re here to help you feel amazing in your body, inside and out. Our holistic program includes a customized plan created with an expert doctor, monthly check-ins and 24/7 messaging, and weight-loss medications. See more

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Sources

Hurtado MD, Tama E, Fansa S, et al. Weight loss response to semaglutide in postmenopausal women with and without hormone therapy use. Menopause. 2024;31(4):266-274. doi:10.1097/GME.0000000000002310.

Mayo Clinic. Weight gain in women at midlife: unique issues in management and the role of menopausal hormone therapy. Endocrinology Update. Published August 2022. Accessed April 7, 2025. https://www.mayoclinic.org/medical-professionals/endocrinology/news/weight-gain-in-women-at-midlife-unique-issues-in-management-and-the-role-of-menopausal-hormone-therapy/mac-20431465